Aesthetic Medicine is constantly evolving, with new approaches and protocols that enhance treatment results. 

In this context, Fractional Radiofrequency and Plasma Jet stand out for stimulating skin regeneration and delivering rejuvenating effects. But did you know it is possible to go further and enhance those results even more?

Combining these techniques with injectable active ingredients and Drug Delivery has proven to be an important differentiator for health and aesthetic professionals who want longer-lasting, more personalized results for their patients.

In this article, you will learn how injectable combinations work and why they can transform the care routine in aesthetic health clinics.
 

Non-invasive treatments: understanding Fractional Radiofrequency and Plasma Jet

Both are non-invasive procedures that deliver visible results without long recovery periods. Here are more details on each one:
 

Fractional Radiofrequency: microneedles to regenerate the skin

Also known as Fractional Microneedled Radiofrequency, this technique uses hypoallergenic (gold-plated) microneedles to stimulate collagen production.

The technology is based on non-ionizing radiation from the electromagnetic spectrum, operating between 30 kHz and 300 MHz. Because it does not interfere with cell metabolism, it is considered safe, effective and non-invasive. 

Its benefits include:

• • Improved skin firmness;

• • Reduced wrinkles;

• • More even skin texture;

• • Faster regeneration in cases of expression lines, skin laxity, atrophic scars, acne marks and stretch marks.

The treatment works in a fractional way, preserving healthy areas of the skin and contributing to faster recovery and longer-lasting results.
 

Plasma Jet: cellular stimulation with long-lasting results 

The Plasma Jet works through a controlled flow of ionized gas that acts on the skin surface, triggering a regeneration process.

It is indicated for:

• • Reducing skin laxity and wrinkles;

• • Softening blemishes;

• • Stimulating the absorption of active ingredients in the dermis.

For this reason, it is frequently used in rejuvenation protocols and is effective in treating expression lines, scars and stretch marks.
 

Injectable combinations: when and why to use them?

Fractional Radiofrequency and Plasma Jet already deliver excellent results, but their effectiveness can be enhanced with injectable combinations.

Specialists recommend applying the injectables after the sessions of these treatments. This prevents the heat generated from compromising the integrity of the active ingredients.

Injectable combinations are minimally invasive procedures, performed with needles or cannulas, with the following purposes:
 

• • Further stimulate collagen production;

• • Improve deep hydration;

• • Prolong the effects of rejuvenation;

• • Treat wrinkles, fine lines, blemishes and skin laxity more effectively.

The choice of the ideal active ingredient depends on the clinical goal and the patient's needs.
 

Injectable combinations: what are the possibilities?

Below, learn about the main injectable active ingredients used in combination with technologies such as Fractional Radiofrequency and Plasma Jet.
 

Skin Booster

Hyaluronic acid-based, Skin Booster promotes deep hydration and improves skin elasticity. It also stimulates collagen and can be applied to several areas, such as the face, neck, décolletage, hands, arms and cheeks.

It is indicated for treating:

• • Acne scars and marks;

• • Dark circles and expression lines;

• • Maintenance of overall skin health.

After treatments such as Radiofrequency and Plasma Jet, skin permeability increases, making it easier for the active ingredients to be absorbed and enhancing the results.
 

Collagen biostimulators

Substances such as calcium hydroxyapatite and polylactic acid stimulate the body's natural collagen production, improving skin texture, firmness and support.

When combined with Radiofrequency or Plasma Jet, they prolong the regenerative effects safely and effectively.

Polydioxanone (PDO) threads

Absorbable and safe, PDO threads produce an immediate lifting effect and also stimulate collagen production.

They are especially indicated for:
 

• • Facial skin laxity;

• • Wrinkles and expression lines on the neck, décolletage and face.

Combining them with aesthetic protocols speeds up tissue regeneration and intensifies results.
 

Drug Delivery: how does the technique promote deep absorption in the dermis? 

Drug Delivery is a technique that applies active ingredients directly to the area of the dermis where they need to act, taking advantage of the skin's increased permeability after aesthetic treatments.

Among the most commonly used active ingredients are:
 

PDRN (Polydeoxyribonucleotide)

This is a tissue bioregenerator derived from salmon DNA, with 95% similarity to human DNA.

It activates specific receptors that trigger anti-inflammatory and regenerative responses. It stimulates:

• • Fibroblasts, osteoblasts and adipocytes;

• • Factors such as VEGF and angiopoietin, improving circulation;

• • Recovery of damaged tissue.

• • It is effective in controlling redness, wrinkles, acne marks and enlarged pores.
   

Exosomes

These are extracellular vesicles produced by stem cells, which play a role in cell communication by carrying genetic information and proteins.

They promote:

• • Collagen synthesis;

• • Reduced inflammation;

• • Deep skin regeneration.
   

What are the benefits of Drug Delivery in post-treatment care?

Injectable active ingredients applied with this technique offer advantages such as:

• • Greater absorption and concentration of the active ingredients;

• • More effective and longer-lasting regeneration;

• • Reduced skin laxity, scars, stretch marks and blemishes;

• • Reinforced effects of Radiofrequency and Plasma Jet;

• • Hydration and stimulation of collagen and elastin production.

Keep in mind: the active ingredients must be approved by ANVISA and applied by trained, qualified professionals.
 

Protocol personalization: the key differentiator for aesthetic clinics

Combining Fractional Radiofrequency and Plasma Jet with injectable techniques and Drug Delivery is not mandatory, but it is a highly effective approach for clinics that want to deliver superior results.

Personalizing protocols makes it possible to meet each patient's needs more precisely. However, it is essential that the professional has technical command of the active ingredients and equipment used, ensuring safety and effectiveness.

Keep reading our blog for more information about the world of aesthetic health and regenerative medicine.