The Fractional Radiofrequency, also known as Microneedled Radiofrequency, has been gaining more and more ground in healthcare thanks to its effective results.

Combined with Radiofrequency (RF), the technology uses microneedles to stimulate collagen production.

In this article, you will learn why Fractional Radiofrequency is a safe treatment for your health and which techniques are associated with the technology. Check it out below!
 

How does Radiofrequency work?

Before addressing the combination with microneedling, and therefore its benefits, it is important to understand how Radiofrequency works in general.

The technology uses non-ionizing radiation from the electromagnetic spectrum, in a range between 30 kilohertz (kHz) and 300 megahertz (MHz). For this reason, it does not damage the functioning of cellular metabolism.

When applied to the skin tissues, Radiofrequency heats the deeper layers of the skin in a controlled way.

This is the secret behind the technology's fast and effective response.
 

What are the effects of the heat generated by Radiofrequency?

Applying Radiofrequency produces heating effects through the conversion or absorption of this energy in the tissues, stimulating the production of proteins that are essential for skin firmness and elasticity, such as collagen.

The rise in temperature stimulates the formation of HSP-47, a protein that protects type I collagen during its synthesis.

It is released as an immediate response to the stress caused by high temperatures.

The hyperthermia generated at the dermal level stimulates the synthesis of these proteins (HSP) inside the cells, causing the expression of TGF-beta-1 (transforming growth factor beta-1), which in turn stimulates HSP-47.
 

Microneedled Radiofrequency: the combination of two technologies

Microneedled Radiofrequency brings together two technologies: microneedling and Radiofrequency. It can also be called Fractional Radiofrequency. That is because the energy emitted is distributed across multiple points directly in the dermis through the microneedles. 
 

What are the applications of Fractional Radiofrequency?

The versatility of the technology comes with high precision and control of the technique. The method improves the skin's natural physiological functions, promoting healthy facial and body rejuvenation by acting on:

• Expression lines;
• Facial and neck “lifting”;
• Stretch marks;
• Skin laxity;
• Atrophic scars;
• Acne marks.
 

Microneedled vs. Conventional Radiofrequency

The microneedling technique, as the name suggests, is performed with several microneedles. Because they are gold-plated, the microneedles are hypoallergenic, ensuring the safety of the procedure.

Microneedled Radiofrequency deposits the greatest amount of energy (heat) in the deeper layers to stimulate collagen formation.

Microneedling combined with Radiofrequency resembles the effect of the fractional laser, producing thermal microinjuries in the tissue in a more homogeneous way.

This approach preserves the adjacent areas, which speeds up healing, shortens recovery time and minimizes discomfort during the procedure.

Studies show that Radiofrequency with microneedling triggers a natural healing response in the body, going through different stages.

In addition to the heat generated, the healing process of these microinjuries also stimulates collagen production. Because of this characteristic, it delivers results 3 times faster than conventional radiofrequency.
 

Combinations related to Fractional Radiofrequency

Thanks to its versatility, there are many combinations that can be performed with Fractional
Radiofrequency technology. Let's look at some of them.
 

Microneedling and Drug Delivery

Drug Delivery is a technique that consists of taking the chosen active ingredient to where it needs to act. In this way, these substances (drugs) are “delivered” directly to specific layers of the skin.

According to the Brazilian Society of Dermatology, Drug Delivery facilitates the delivery of therapeutic molecules to the areas of the skin being treated, whether on the face or the body.

Drug Delivery has shown promising results. Alongside Radiofrequency, cosmetic actives (for topical use) permeate the skin through the microneedles to enhance the expected effects.

The benefits of this technique combined with the technology are many:

• The actives penetrate deeper and in a more concentrated way;
• Collagen and elastin stimulation for better skin firmness;
• The choice of actives can be adapted to each patient's needs;
• It allows the treatment of different conditions such as skin laxity, spots, acne scars and stretch marks;
• Combining the two technologies enhances results;
• Safe, minimally invasive procedure.
 

PDRN and Exosomes

Regenerative medicine treatments with PDRN (Polydeoxyribonucleotide) and Exosomes have shown important results in rejuvenating and revitalizing the skin.

These tissue bioregenerators represent a new generation of treatments in aesthetic health, focused on stimulating the body's natural ability to regenerate.
 

What are Exosomes and what are their benefits?

Exosomes are extracellular vesicles produced by stem cells and play a key role as signaling agents in the body.

Working as messengers, they carry genetic information and proteins directly to cells, facilitating cellular communication and coordination. Their action is particularly beneficial in regeneration and repair processes.

Exosomes speed up healing, increase the production of collagen and elastin, and help control skin pigmentation.

In addition, they are rich in growth factors and proteins that stimulate cell regeneration and help repair damage, contributing significantly to skin health and rejuvenation.
 

What is PDRN?

PDRN, or polydeoxyribonucleotide, is a highly purified and sterilized DNA mixture obtained from salmon sperm, which is 95% similar to human DNA.

This compound specifically activates the adenosine A2A receptor on cells, triggering the release of cytokines such as Interleukin-10 (IL-10), which have anti-inflammatory effects and help repair damaged cells.

Activation of this receptor stimulates the proliferation of osteoblasts, fibroblasts and adipose precursor cells, rejuvenating and activating aged cells.

In addition, PDRN also promotes the release of VEGF, angiopoietin and glutamine transferase II, improving blood circulation and speeding up cell regeneration.
 

What are the benefits of PDRN for the skin?

PDRN offers a number of notable benefits for the skin. It promotes tissue regeneration, helping the skin recover and renew itself.

In addition, it is effective in controlling inflammation and redness, significantly improving the appearance of the skin.

Healing processes are optimized with the use of PDRN, which also helps soften acne marks and enlarged pores, in addition to reducing wrinkles.

Another important advantage is the repair of the skin barrier, which strengthens the skin's natural protection.

PDRN also provides an extra layer of protection against damage caused by UV rays, helping to preserve skin integrity and prevent premature aging.
 

Conclusions on Microneedled Radiofrequency and its combinations

Fractional or Microneedled Radiofrequency stands out as a safe and effective technology for improving the skin's natural physiological functions, which decline over time due to genetic factors and
lifestyle.

Its ability to stimulate collagen production, combined with the possibility of applying specific actives, delivers remarkable, personalized results.

Microneedled Radiofrequency, with its various combinations, offers a range of possibilities for treating different conditions, opening the door to a more effective and satisfying skin care journey.

Keep reading our blog for more information about the world of aesthetic health and regenerative medicine.